Our human body is composed of 37 trillion cells. In addition to cells, various non-cellular components including proteins and sugars that surround cells are also major constituents of the body. These non-cellular components called extracellular matrix regulate various cellular behaviors and fates (cell growth, migration, and differentiation) as extracellular environments. Cells cooperate with each other to maintain homeostasis in vivo. These regulation and cooperation are prerequisite for multicellular organisms. Abnormalities in regulation and cooperation in the body lead to various diseases such as cancer and hyperlipidemia.
The goal of our research is to understand the mechanisms of various “cellular” and physiological events from the viewpoint of “biochemistry” of genes and proteins. In particular, we have been analyzing the mechanism by which extracellular matrix, such as collagen, regulate cell growth and differentiation and the functions of transporters involved in maintaining the homeostasis of biological substances such as cholesterol.
|Hiroshi Tachibana’s paper “Plasma membrane of focal adhesions has a high content of cholesterol and phosphatidylcholine with saturated acyl chains” was accepted to Journal of Cell Science.|
|We welcomed new undergraduates and a graduate student to Seika Laboratory.|
|Ryota Futamata’s paper”Cholesterol accumulation in ovarian follicles causes ovulation defects in Abca1a-/- Japanese medaka (Oryzias latipes).” was accepted to Heliyon.|
|At the 16th Annual Meeting of JTRA, D3 Kazuki Sakata won the Annual Award.|
|We welcomed new undergraduates and graduate students to Seika Laboratory.|